CFHR4
Sign in to saveAlso known as CFHL4, FHR-4, FHR4, complement factor H related 4
Complement factor H-related protein 4 is a protein that in humans is encoded by the CFHR4 gene.
In the Vinony graph
Within Vinony's link graph, CFHR4 is referenced by 2 other articles, and connects out to PubMed, human chromosome 1 and Ensembl genome database project.
It is catalogued under the topic Genes on human chromosome 1.
Its subject is documented across 6 Wikipedia language editions.
Gene data
CFHR4- Name
- complement factor H related 4
- Type
- protein-coding
- Position
- 196,888,014–196,920,294 (+)
- Aliases
- CFHL4, FHR-4, FHR4
- Ensembl
- ENSG00000134365
- RefSeq RNA
- NM_001201550.3, NM_001201551.2, NM_006684.5, XM_017000111.2, XM_017000113.2
- RefSeq protein
- NP_001188479.1, NP_001188480.1, NP_006675.2, XP_016855600.1, XP_016855602.1
This gene is a member of the complement factor H (CFH) gene family, and encodes one of the 5 CFH-related (CFHR) proteins. These 5 genes are closely linked to the CFH gene on chromosome 1q31-q32. The CFHRs are secreted plasma proteins synthesized primarily by the hepatocytes, and composed of highly-related short consensus repeats (SCRs). This protein enhances the cofactor activity of CFH, and is involved in complement regulation. It can associate with lipoproteins and may play a role in lipid metabolism. Alternatively spliced transcript variants encoding different isoforms (varying in the number of SCRs) have been described for this gene. [provided by RefSeq, Jan 2011].
Gene Ontology
Biological process
Molecular function
Cellular component
Pathways
via MyGene.info
Gene · Ensembl
complement factor H related 4
- Symbol
- CFHR4
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 1:196,888,014-196,920,294
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 7 more facts
- HomoloGene ID
- 136449
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/10877
- genomic end
- 196918713
- genomic start
- 196888014
- chromosome
- human chromosome 1
- cytogenetic location
- 1q31.3
Sources (3)
via Wikidata · CC0
~1 min read
Encyclopedic overview
3 sectionsContents
- References
- Further reading
- External links
Complement factor H-related protein 4 is a protein that in humans is encoded by the CFHR4 gene.
==References==
Excerpted from Wikipedia’s “CFHR4” article, available under the CC BY-SA 4.0 licence.