CFP
Also known as BFD, PFC, PFD, PROPERDIN, complement factor properdin, properdin
Properdin is a protein that in humans is encoded by the CFP (complement factor properdin) gene.
Gene data
CFP- Name
- complement factor properdin
- Type
- protein-coding
- Chromosome
- X
- Aliases
- BFD, PFC, PFD, PROPERDIN
This gene encodes a plasma glycoprotein that positively regulates the alternative complement pathway of the innate immune system. This protein binds to many microbial surfaces and apoptotic cells and stabilizes the C3- and C5-convertase enzyme complexes in a feedback loop that ultimately leads to formation of the membrane attack complex and lysis of the target cell. Mutations in this gene result in two forms of properdin deficiency, which results in high susceptibility to meningococcal infections. Multiple alternatively spliced variants, encoding the same protein, have been identified.[provided by RefSeq, Feb 2009].
via MyGene.info
Article
6 sectionsContents
- Structure
- Function
- History
- Deficiency
- References
- External links
Properdin is a protein that in humans is encoded by the CFP (complement factor properdin) gene.
Properdin is plasma glycoprotein that activates the complement system of the innate immune system. This protein binds to bacterial cell walls and dying human cells to stabilize the C3 and C5-convertase enzyme complexes to form an attack complex that leads to the lysis of the cell.