FUS

Also known as ALS6, ETM4, FUS1, HNRNPP2, POMP75, TLS, FUS RNA binding protein, altFUS

protein-coding gene in the species Homo sapiens

Gene data

FUS

Name: FUS RNA binding protein
Type: protein-coding
Position: 31,180,134–31,196,963 (+)
Aliases: ALS6, ETM4, FUS1, HNRNPP2, POMP75, TLS, altFUS
Ensembl: ENSG00000089280
RefSeq RNA: NM_001010850.1, NM_001170634.1, NM_001170937.1, NM_004960.4, NR_028388.2
RefSeq protein: NP_001164105.1, NP_001164408.1, NP_004951.1, XP_011544083.1, XP_011544084.1

This gene encodes a multifunctional protein component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complex. The hnRNP complex is involved in pre-mRNA splicing and the export of fully processed mRNA to the cytoplasm. This protein belongs to the FET family of RNA-binding proteins which have been implicated in cellular processes that include regulation of gene expression, maintenance of genomic integrity and mRNA/microRNA processing. Alternative splicing results in multiple transcript variants. Defects in this gene result in amyotrophic lateral sclerosis type 6. [provided by RefSeq, Sep 2009].