DDIT3

Name

DNA damage inducible transcript 3

Type

protein-coding

Position

57,516,584–57,523,630 (−)

Aliases

AltDDIT3, C/EBPzeta, CEBPZ, CHOP, CHOP-10, CHOP10, GADD153

Ensembl

ENSG00000175197

RefSeq RNA

NM_001195053.1, NM_001195054.1, NM_001195055.1, NM_001195056.1, NM_001195057.1

RefSeq protein

NP_001181982.1, NP_001181983.1, NP_001181984.1, NP_001181985.1, NP_001181986.1

This gene encodes a member of the CCAAT/enhancer-binding protein (C/EBP) family of transcription factors. The protein functions as a dominant-negative inhibitor by forming heterodimers with other C/EBP members, such as C/EBP and LAP (liver activator protein), and preventing their DNA binding activity. The protein is implicated in adipogenesis and erythropoiesis, is activated by endoplasmic reticulum stress, and promotes apoptosis. Fusion of this gene and FUS on chromosome 16 or EWSR1 on chromosome 22 induced by translocation generates chimeric proteins in myxoid liposarcomas or Ewing sarcoma. Multiple alternatively spliced transcript variants encoding two isoforms with different length have been identified. [provided by RefSeq, Aug 2010].

via MyGene.info

Gene · Ensembl

DNA damage inducible transcript 3

Symbol

DDIT3

Biotype

Protein coding

Organism

Homo sapiens

Location

12:57,516,584-57,523,630

Strand

Reverse (−)

Assembly

GRCh38

Wikidata facts

Instance of

gene

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