RHEB

Also known as RHEB2, Ras homolog enriched in brain, Ras homolog, mTORC1 binding

RHEB also known as Ras homolog enriched in brain (RHEB) is a GTP-binding protein that is ubiquitously expressed in humans and other mammals. The protein is largely involved in the mTOR pathway and the regulation of the cell cycle.

Gene data

RHEB

Name: Ras homolog, mTORC1 binding
Type: protein-coding
Position: 151,466,012–151,520,120 (−)
Aliases: RHEB2
Ensembl: ENSG00000106615
RefSeq RNA: NM_005614.4, XM_011516457.3, XM_024446854.2, XM_047420685.1, XM_054358755.1
RefSeq protein: NP_005605.1, XP_011514759.1, XP_024302622.1, XP_047276641.1, XP_054214730.1

This gene is a member of the small GTPase superfamily and encodes a lipid-anchored, cell membrane protein with five repeats of the RAS-related GTP-binding region. This protein is vital in regulation of growth and cell cycle progression due to its role in the insulin/TOR/S6K signaling pathway. The protein has GTPase activity and shuttles between a GDP-bound form and a GTP-bound form, and farnesylation of the protein is required for this activity. Three pseudogenes have been mapped, two on chromosome 10 and one on chromosome 22. [provided by RefSeq, Jul 2008].

Gene Ontology

Biological process

signal transduction

Article

12 sections

Contents

Structure
Function
Activation of mTORC1
mTORC1 independent functions
Other functions
Differences from Ras superfamily
Regulation
Tuberous sclerosis
Interactions
References
Further reading
External links

RHEB is a member of the Ras superfamily. Being a relative of Ras, the overexpression of RHEB can be seen in multiple human carcinomas. For this reason, ways to inhibit RHEB to control the mTOR pathway are studied as possible treatments for uncontrollable tumor cell growth in several diseases, especially in tuberous sclerosis.