RHEB
Sign in to saveAlso known as RHEB2, Ras homolog enriched in brain, Ras homolog, mTORC1 binding
RHEB also known as Ras homolog enriched in brain (RHEB) is a GTP-binding protein that is ubiquitously expressed in humans and other mammals. The protein is largely involved in the mTOR pathway and the regulation of the cell cycle.
Gene data
RHEB- Name
- Ras homolog, mTORC1 binding
- Type
- protein-coding
- Position
- 151,466,012–151,520,120 (−)
- Aliases
- RHEB2
- Ensembl
- ENSG00000106615
- RefSeq RNA
- NM_005614.4, XM_011516457.3, XM_024446854.2, XM_047420685.1, XM_054358755.1
- RefSeq protein
- NP_005605.1, XP_011514759.1, XP_024302622.1, XP_047276641.1, XP_054214730.1
This gene is a member of the small GTPase superfamily and encodes a lipid-anchored, cell membrane protein with five repeats of the RAS-related GTP-binding region. This protein is vital in regulation of growth and cell cycle progression due to its role in the insulin/TOR/S6K signaling pathway. The protein has GTPase activity and shuttles between a GDP-bound form and a GTP-bound form, and farnesylation of the protein is required for this activity. Three pseudogenes have been mapped, two on chromosome 10 and one on chromosome 22. [provided by RefSeq, Jul 2008].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
Ras homolog, mTORC1 binding
- Symbol
- RHEB
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 7:151,465,976-151,520,120
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Image
- Protein RHEB PDB 1xtq.png
Show 6 more facts
- HomoloGene ID
- 123916
- exact match
- identifiers.org/ncbigene/6009
- genomic end
- 151217206
- genomic start
- 151163098
- cytogenetic location
- 7q36.1
- Commons category
- GTP-binding protein RheB
Sources (7)
via Wikidata · CC0
~6 min read
Article
12 sectionsContents
- Structure
- Function
- Activation of mTORC1
- mTORC1 independent functions
- Other functions
- Differences from Ras superfamily
- Regulation
- Tuberous sclerosis
- Interactions
- References
- Further reading
- External links
RHEB also known as Ras homolog enriched in brain (RHEB) is a GTP-binding protein that is ubiquitously expressed in humans and other mammals. The protein is largely involved in the mTOR pathway and the regulation of the cell cycle.
RHEB is a member of the Ras superfamily. Being a relative of Ras, the overexpression of RHEB can be seen in multiple human carcinomas. For this reason, ways to inhibit RHEB to control the mTOR pathway are studied as possible treatments for uncontrollable tumor cell growth in several diseases, especially in tuberous sclerosis.