RAP1A

Name

RAP1A, member of RAS oncogene family

Type

protein-coding

Position

111,542,218–111,716,691 (+)

Aliases

C21KG, G-22K, KREV-1, KREV1, RAP1, SMGP21

Ensembl

ENSG00000116473

RefSeq RNA

NM_001010935.3, NM_001291896.3, NM_001370216.2, NM_001370217.2, NM_001394066.1

RefSeq protein

NP_001010935.1, NP_001278825.1, NP_001357145.1, NP_001357146.1, NP_001380995.1

This gene encodes a member of the Ras family of small GTPases. The encoded protein undergoes a change in conformational state and activity, depending on whether it is bound to GTP or GDP. This protein is activated by several types of guanine nucleotide exchange factors (GEFs), and inactivated by two groups of GTPase-activating proteins (GAPs). The activation status of the encoded protein is therefore affected by the balance of intracellular levels of GEFs and GAPs. The encoded protein regulates signaling pathways that affect cell proliferation and adhesion, and may play a role in tumor malignancy. Pseudogenes of this gene have been defined on chromosomes 14 and 17. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014].

via MyGene.info

Gene · Ensembl

RAP1A, member of RAS oncogene family

Symbol

RAP1A

Biotype

Protein coding

Organism

Homo sapiens

Location

1:111,542,009-111,716,691

Strand

Forward (+)

Assembly

GRCh38

Wikidata facts

Image

Protein RAP1A PDB 1c1y.png

via Wikidata · CC0