TNFAIP3
Sign in to saveAlso known as A20, OTUD7C, TNFA1P2, AISBL, TNF alpha induced protein 3, AIFBL1
Tumor necrosis factor, alpha-induced protein 3 or A20 is a protein that in humans is encoded by the TNFAIP3 gene.
In the Vinony graph
Vinony's link graph records 29 inbound references to TNFAIP3, and connects out to Q180686, Ensembl genome database project and protein.
It is catalogued under the topic Genes on human chromosome 6.
Vinony links it to 7 Wikipedia language editions.
Gene data
TNFAIP3- Name
- TNF alpha induced protein 3
- Type
- protein-coding
- Position
- 137,866,383–137,885,836 (+)
- Aliases
- A20, AIFBL1, AISBL, OTUD7C, TNFA1P2
- Ensembl
- ENSG00000118503
- RefSeq RNA
- NM_001270507.2, NM_001270508.2, NM_006290.4, XM_005267119.1, XM_011536095.2
- RefSeq protein
- NP_001257436.1, NP_001257437.1, NP_006281.1, XP_005267176.1, XP_011534397.1
This gene was identified as a gene whose expression is rapidly induced by the tumor necrosis factor (TNF). The protein encoded by this gene is a zinc finger protein and ubiqitin-editing enzyme, and has been shown to inhibit NF-kappa B activation as well as TNF-mediated apoptosis. The encoded protein, which has both ubiquitin ligase and deubiquitinase activities, is involved in the cytokine-mediated immune and inflammatory responses. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2012].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
TNF alpha induced protein 3
- Symbol
- TNFAIP3
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 6:137,866,383-137,885,836
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Image
- Protein TNFAIP3 PDB 2EQE.png
Show 5 more facts
- HomoloGene ID
- 4582
- exact match
- identifiers.org/ncbigene/7128
- genomic end
- 138204449
- genomic start
- 137867214
- cytogenetic location
- 6q23.3
via Wikidata · CC0
~2 min read
Encyclopedic overview
7 sectionsContents
- Interactions
- Association with rheumatoid arthritis
- Other diseases
- See also
- References
- Further reading
- External links
Tumor necrosis factor, alpha-induced protein 3 or A20 is a protein that in humans is encoded by the TNFAIP3 gene.
This gene was identified as a gene whose expression is rapidly induced by the tumor necrosis factor (TNF). The protein encoded by this gene is a zinc finger protein and a deubiquitinating enzyme, and has been shown to inhibit NF-kappa B activation as well as TNF-mediated apoptosis. The A20 protein is ancient, and protein homolog can be found as far back as cnidaria (corals, jellyfish, anemones) with a conserved protein domain composition. Using knockout mouse models of TNFAIP3 and its transcriptional repressor (i.e. KCHIP3), TNFAIP3 has been shown to be critical for limiting inflammation by terminating endotoxin- and TNF-induced NF-kappa B responses. In brief, deubiquitinase function of TNFAIP3 was shown to remove ubiquitin chains from VE-cadherin to prevent loss of VE-cadherin at the endothelial adherens junctions.
Excerpted from Wikipedia’s “TNFAIP3” article, available under the CC BY-SA 4.0 licence.