TNFAIP3
Sign in to saveAlso known as A20, OTUD7C, TNFA1P2, AISBL, TNF alpha induced protein 3, AIFBL1
Tumor necrosis factor, alpha-induced protein 3 or A20 is a protein that in humans is encoded by the TNFAIP3 gene.
Gene data
TNFAIP3- Name
- TNF alpha induced protein 3
- Type
- protein-coding
- Position
- 137,866,383–137,885,836 (+)
- Aliases
- A20, AIFBL1, AISBL, OTUD7C, TNFA1P2
- Ensembl
- ENSG00000118503
- RefSeq RNA
- NM_001270507.2, NM_001270508.2, NM_006290.4, XM_005267119.1, XM_011536095.2
- RefSeq protein
- NP_001257436.1, NP_001257437.1, NP_006281.1, XP_005267176.1, XP_011534397.1
This gene was identified as a gene whose expression is rapidly induced by the tumor necrosis factor (TNF). The protein encoded by this gene is a zinc finger protein and ubiqitin-editing enzyme, and has been shown to inhibit NF-kappa B activation as well as TNF-mediated apoptosis. The encoded protein, which has both ubiquitin ligase and deubiquitinase activities, is involved in the cytokine-mediated immune and inflammatory responses. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2012].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
TNF alpha induced protein 3
- Symbol
- TNFAIP3
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 6:137,866,383-137,885,836
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Image
- Protein TNFAIP3 PDB 2EQE.png
Show 5 more facts
- HomoloGene ID
- 4582
- exact match
- identifiers.org/ncbigene/7128
- genomic end
- 138204449
- genomic start
- 137867214
- cytogenetic location
- 6q23.3
via Wikidata · CC0
~2 min read
Article
7 sectionsContents
- Interactions
- Association with rheumatoid arthritis
- Other diseases
- See also
- References
- Further reading
- External links
Tumor necrosis factor, alpha-induced protein 3 or A20 is a protein that in humans is encoded by the TNFAIP3 gene.
This gene was identified as a gene whose expression is rapidly induced by the tumor necrosis factor (TNF). The protein encoded by this gene is a zinc finger protein and a deubiquitinating enzyme, and has been shown to inhibit NF-kappa B activation as well as TNF-mediated apoptosis. The A20 protein is ancient, and protein homolog can be found as far back as cnidaria (corals, jellyfish, anemones) with a conserved protein domain composition. Using knockout mouse models of TNFAIP3 and its transcriptional repressor (i.e. KCHIP3), TNFAIP3 has been shown to be critical for limiting inflammation by terminating endotoxin- and TNF-induced NF-kappa B responses. In brief, deubiquitinase function of TNFAIP3 was shown to remove ubiquitin chains from VE-cadherin to prevent loss of VE-cadherin at the endothelial adherens junctions.