IRF1

Also known as IRF-1, MAR, interferon regulatory factor 1

Interferon regulatory factor 1 is a protein that in humans is encoded by the IRF1 gene.

Gene data

IRF1

Name: interferon regulatory factor 1
Type: protein-coding
Aliases: IMD117, IRF-1, MAR

The protein encoded by this gene is a transcriptional regulator and tumor suppressor, serving as an activator of genes involved in both innate and acquired immune responses. The encoded protein activates the transcription of genes involved in the body's response to viruses and bacteria, playing a role in cell proliferation, apoptosis, the immune response, and DNA damage response. This protein represses the transcription of several other genes. As a tumor suppressor, it both suppresses tumor cell growth and stimulates an immune response against tumor cells. Defects in this gene have been associated with gastric cancer, myelogenous leukemia, and lung cancer. [provided by RefSeq, Aug 2017].

via MyGene.info

Gene · Ensembl

interferon regulatory factor 1

Symbol: IRF1
Biotype: Protein coding
Organism: Homo sapiens
Location: 5:132,440,440-132,508,719
Strand: Reverse (−)
Assembly: GRCh38

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via Ensembl · EMBL-EBI

Wikidata facts

Image: Protein IRF1 PDB 1if1.png

Show 3 more facts

HomoloGene ID: 1658
exact match: identifiers.org/ncbigene/3659
Commons category: Interferon regulatory factor 1 (IRF-1)

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Article

7 sections

Contents

Function
Regulation
Interactions
See also
References
Further reading
External links

Interferon regulatory factor 1 is a protein that in humans is encoded by the IRF1 gene.

== Function == Interferon regulatory factor 1 was the first member of the interferon regulatory transcription factor (IRF) family identified. Initially described as a transcription factor able to activate expression of the cytokine Interferon beta, IRF-1 was subsequently shown to function as a transcriptional activator or repressor of a variety of target genes. IRF-1 regulates expression of target genes by binding to an interferon stimulated response element (ISRE) in their promoters. The IRF-1 protein binds to the ISRE via an N-terminal helix-turn-helix DNA binding domain, which is highly conserved among all IRF proteins.