EBF1

Also known as COE1, EBF, O/E-1, OLF1, early B-cell factor 1, early B cell factor 1, EBF transcription factor 1

Transcription factor COE1 is a protein that in humans is encoded by the EBF1 gene. EBF1 stands for Early B-Cell Factor 1.

Gene data

EBF1

Name: EBF transcription factor 1
Type: protein-coding
Position: 158,695,920–159,099,951 (−)
Aliases: COE1, EBF, O/E-1, OLF1
Ensembl: ENSG00000164330
RefSeq RNA: NM_001290360.3, NM_001324101.2, NM_001324103.2, NM_001324106.2, NM_001324107.2
RefSeq protein: NP_001277289.1, NP_001311030.1, NP_001311032.1, NP_001311035.1, NP_001311036.1

Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II. Predicted to act upstream of or within positive regulation of transcription, DNA-templated. Predicted to be located in nucleus. Predicted to be part of chromatin. [provided by Alliance of Genome Resources, Apr 2022]

Gene Ontology

Biological process

regulation of DNA-templated transcription regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II

Molecular function

RNA polymerase II cis-regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription activator activity, RNA polymerase II-specific DNA binding DNA-binding transcription factor activity protein binding

Cellular component

chromatin nucleus nucleus

Pathways

Developmental Biology Transcriptional regulation of white adipocyte differentiation Olfactory Signaling Pathway Sensory Perception Expression and translocation of olfactory receptors Adipogenesis Adipogenesis Prion disease pathway White fat cell differentiation

via MyGene.info

Gene · Ensembl

EBF transcription factor 1

Symbol: EBF1
Biotype: Protein coding
Organism: Homo sapiens
Location: 5:158,695,920-159,100,331
Strand: Reverse (−)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Image: Protein EBF1 PDB 3LYR.png

Show 5 more facts

HomoloGene ID: 7297
exact match: identifiers.org/ncbigene/1879
genomic end: 159099916
genomic start: 158122928
cytogenetic location: 5q33.3

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Transcription factor COE1 is a protein that in humans is encoded by the EBF1 gene. EBF1 stands for Early B-Cell Factor 1.

EBF1 controls the expression of key proteins required for B cell differentiation, signal transduction and function. The crucial role of this factor is shown in the regulation of expression of SLAM family co-receptors in B-cells. In addition, EBF1 is also noted for its role in chondrogenic differentiation in limb bud mesenchymal progenitor cells.