EIF2S1
Sign in to saveAlso known as EIF-2, EIF-2A, EIF-2alpha, EIF2, EIF2A, eukaryotic translation initiation factor 2 subunit alpha
Eukaryotic translation initiation factor 2 subunit 1 (eIF2α) is a protein that in humans is encoded by the EIF2S1 gene.
Gene data
EIF2S1- Name
- eukaryotic translation initiation factor 2 subunit alpha
- Type
- protein-coding
- Position
- 67,359,993–67,394,395 (+)
- Aliases
- EIF-2, EIF-2A, EIF-2alpha, EIF2, EIF2A
- Ensembl
- ENSG00000134001
- RefSeq RNA
- NM_004094.5
- RefSeq protein
- NP_004085.1
The translation initiation factor EIF2 catalyzes the first regulated step of protein synthesis initiation, promoting the binding of the initiator tRNA to 40S ribosomal subunits. Binding occurs as a ternary complex of methionyl-tRNA, EIF2, and GTP. EIF2 is composed of 3 nonidentical subunits, the 36-kD EIF2-alpha subunit (EIF2S1), the 38-kD EIF2-beta subunit (EIF2S2; MIM 603908), and the 52-kD EIF2-gamma subunit (EIF2S3; MIM 300161). The rate of formation of the ternary complex is modulated by the phosphorylation state of EIF2-alpha (Ernst et al., 1987 [PubMed 2948954]).[supplied by OMIM, Feb 2010].
Gene Ontology
Biological process
Molecular function
Cellular component
Pathways
via MyGene.info
Gene · Ensembl
eukaryotic translation initiation factor 2 subunit alpha
- Symbol
- EIF2S1
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 14:67,359,993-67,394,395
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
~2 min read
Encyclopedic overview
6 sectionsContents
- Function
- Clinical significance
- Dephosphorylation inhibitors
- See also
- References
- Further reading
Eukaryotic translation initiation factor 2 subunit 1 (eIF2α) is a protein that in humans is encoded by the EIF2S1 gene.
== Function ==
Excerpted from Wikipedia’s “EIF2S1” article, available under the CC BY-SA 4.0 licence.