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GeneQ17916309· pop 6· linked from 5 articles

ELF1

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Also known as E74 like ETS transcription factor 1, EFTUD1, RIA1

E74-like factor 1 (ets domain transcription factor) is a protein that in humans is encoded by the ELF1 gene.

Gene data

ELF1

Name: E74 like ETS transcription factor 1
Type: protein-coding
Position: 40,931,241–41,061,692 (−)
Aliases: EFTUD1, RIA1
Ensembl: ENSG00000120690
RefSeq RNA: NM_001145353.1, NM_001370329.1, NM_001370330.1, NM_001370331.1, NM_001370332.1
RefSeq protein: NP_001138825.1, NP_001357258.1, NP_001357259.1, NP_001357260.1, NP_001357261.1

This gene encodes an E26 transformation-specific related transcription factor. The encoded protein is primarily expressed in lymphoid cells and acts as both an enhancer and a repressor to regulate transcription of various genes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2009].

Gene Ontology

Biological process

regulation of DNA-templated transcription regulation of transcription by RNA polymerase II regulation of transcription by RNA polymerase II cell differentiation positive regulation of DNA-templated transcription positive regulation of DNA-templated transcription positive regulation of DNA-templated transcription positive regulation of transcription by RNA polymerase II

Molecular function

RNA polymerase II cis-regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription factor activity DNA-binding transcription factor activity

Cellular component

chromatin nucleus nucleus nucleus nucleus nucleoplasm nucleoplasm

Pathways

Generic Transcription Pathway RNA Polymerase II Transcription Gene expression (Transcription)Transcriptional regulation by RUNX1 RUNX1 regulates transcription of genes involved in BCR signaling RUNX1 regulates transcription of genes involved in interleukin signaling

via MyGene.info

Gene · Ensembl

E74 like ETS transcription factor 1

Symbol: ELF1
Biotype: Protein coding
Organism: Homo sapiens
Location: 13:40,931,241-41,061,692
Strand: Reverse (−)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of: gene

Show 9 more facts

HomoloGene ID: 7303
genetic association: systemic lupus erythematosus
found in taxon: Homo sapiens
exact match: identifiers.org/ncbigene/1997
genomic end: 41635576
genomic start: 40931924
chromosome: human chromosome 13
cytogenetic location: 13q14.11
expressed in: urethra

Sources (5)

via Wikidata · CC0

~1 min read

Encyclopedic overview

3 sections

Contents

Function
References
Further reading

E74-like factor 1 (ets domain transcription factor) is a protein that in humans is encoded by the ELF1 gene.

==Function==

Excerpted from Wikipedia’s “ELF1” article, available under the CC BY-SA 4.0 licence.

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