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Nitric oxide synthase 3
Sign in to saveAlso known as nitric oxide synthase 3 transcript variant eNOS-delta21, nitric oxide synthase 3 (endothelial cell), nitric oxide synthase 3 transcript variant eNOS-delta20, Nitric Oxide Synthase Type III, NOS type III, eNOS, EC-NOS, endothelial NOS
mammalian protein found in Homo sapiens
In the Vinony graph
Within Vinony's link graph, Nitric oxide synthase 3 is referenced by 467 other articles, and connects out to nitric oxide synthase, Wikidata and PubMed.
It is catalogued under topics including EC 1.14.13 and Genes on human chromosome 7.
Its subject is documented across 11 Wikipedia language editions.
Protein · UniProt
Nitric oxide synthase 3
- Gene
- NOS3
- Organism
- Homo sapiens (Human)
- Length
- 1,203 aa
- Molecular mass
- 133,275 Da
- Evidence
- 1: Evidence at protein level
Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway (PubMed:1378832). NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets
Swiss-Prot (reviewed) · via UniProt
Research
4,572 papers- Endothelial nitric oxide synthase-derived nitric oxide in the regulation of metabolism.F1000Research · 2020
- The nitric oxide synthase 3 G894T polymorphism associated with Alzheimer's disease risk: a meta-analysis.Scientific reports · 2015
- The relationship of nitric oxide synthase 3(NOS3) gene polymorphism in the risk of pulmonary arterial hypertension: A systematic review and meta-analysis.Nitric oxide : biology and chemistry · 2025
- Nitric oxide synthase 3 gene variants and colorectal cancer: a meta-analysis.Asian Pacific journal of cancer prevention : APJCP · 2014
- Associations between nitric oxide synthase 3 gene polymorphisms and preeclampsia risk: a meta-analysis.Scientific reports · 2016
via PubMed
Clinical Trials
18 registered- PHASE2ACTIVE_NOT_RECRUITING9-ING-41 Plus Carboplatin in Salivary Gland CarcinomaGlenn J. Hanna · NCT05010629
- UNKNOWNSelective Screening of Children for Hereditary Metabolic Diseases by Tandem Mass Spectrometry in KazakhstanWest Kazakhstan Medical University · NCT05910151
- NAUNKNOWNFat and Sugar Metabolism During Exercise in Patients With Metabolic MyopathyRigshospitalet, Denmark · NCT02635269
- PHASE2WITHDRAWN9-ING-41 Plus Carboplatin in Patients With Advanced, Metastatic Salivary Gland CarcinomaActuate Therapeutics Inc. · NCT04832438
- PHASE3RECRUITINGA Study to Investigate Efficacy and Safety of Pegtibatinase Compared With Placebo in Participants ≥12 to ≤65 Years of Age With Classical Homocystinuria (HCU) Due to Cystathionine Beta Synthase Deficiency Receiving Standard of Care TreatmentTravere Therapeutics, Inc. · NCT06247085
- NACOMPLETEDThe Impact of Fish-oil Fatty Acids on Postprandial Vascular ReactivityUniversity of East Anglia · NCT01692431
Wikidata facts
- Instance of
- protein
- Subclass of
- nitric oxide synthase
Show 3 more facts
- found in taxon
- Homo sapiens
- exact match
- purl.uniprot.org/uniprot/P29474
- physically interacts with
- nitroarginine
Sources (3)
via Wikidata · CC0