EGLN3
Sign in to saveAlso known as HIFP4H3, HIFPH3, PHD3, egl-9 family hypoxia inducible factor 3
Egl nine homolog 3 is a protein that in humans is encoded by the EGLN3 gene. ELGN3 is a member of the superfamily of alpha-ketoglutarate-dependent hydroxylases, which are non-haem iron-containing proteins.
Gene data
EGLN3- Name
- egl-9 family hypoxia inducible factor 3
- Type
- protein-coding
- Position
- 33,924,221–34,462,774 (−)
- Aliases
- HIFP4H3, HIFPH3, PHD3
- Ensembl
- ENSG00000129521
- RefSeq RNA
- NM_001308103.2, NM_022073.4
- RefSeq protein
- NP_001295032.1, NP_071356.1
Enables peptidyl-proline 4-dioxygenase activity. Involved in several processes, including activation of cysteine-type endopeptidase activity involved in apoptotic process; peptidyl-proline hydroxylation to 4-hydroxy-L-proline; and response to hypoxia. Located in cytosol and nucleus. Implicated in renal cell carcinoma. Biomarker of clear cell renal cell carcinoma. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
egl-9 family hypoxia inducible factor 3
- Symbol
- EGLN3
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 14:33,924,221-34,462,774
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 8 more facts
- HomoloGene ID
- 32531
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/112399
- genomic end
- 34931980
- genomic start
- 33924227
- chromosome
- human chromosome 14
- cytogenetic location
- 14q13.1
- expressed in
- amygdala
Sources (4)
via Wikidata · CC0
~1 min read
Encyclopedic overview
2 sectionsContents
- References
- Further reading
Egl nine homolog 3 is a protein that in humans is encoded by the EGLN3 gene. ELGN3 is a member of the superfamily of alpha-ketoglutarate-dependent hydroxylases, which are non-haem iron-containing proteins.
== References ==
Excerpted from Wikipedia’s “EGLN3” article, available under the CC BY-SA 4.0 licence.