FMO5
Sign in to saveAlso known as flavin containing monooxygenase 5, flavin containing dimethylaniline monoxygenase 5, hBVMO1
Dimethylaniline monooxygenase [N-oxide-forming] 5 is an enzyme in humans encoded by the FMO5 gene.
Gene data
FMO5- Name
- flavin containing dimethylaniline monoxygenase 5
- Type
- protein-coding
- Aliases
- hBVMO1
Metabolic N-oxidation of the diet-derived amino-trimethylamine (TMA) is mediated by flavin-containing monooxygenase and is subject to an inherited FMO3 polymorphism in man resulting in a small subpopulation with reduced TMA N-oxidation capacity resulting in fish odor syndrome Trimethylaminuria. Three forms of the enzyme, FMO1 found in fetal liver, FMO2 found in adult liver, and FMO3 are encoded by genes clustered in the 1q23-q25 region. Flavin-containing monooxygenases are NADPH-dependent flavoenzymes that catalyzes the oxidation of soft nucleophilic heteroatom centers in drugs, pesticides, and xenobiotics. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2009].
via MyGene.info
Gene · Ensembl
flavin containing dimethylaniline monoxygenase 5
- Symbol
- FMO5
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 1:147,175,351-147,243,050
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
Show 5 more facts
- HomoloGene ID
- 68185
- exact match
- identifiers.org/ncbigene/2330
- genomic start
- 146646930
- genomic end
- 146714700
- cytogenetic location
- 1q21.1
Sources (4)
via Wikidata · CC0
~1 min read
Article
3 sectionsContents
- Related gene problems
- References
- Further reading
Dimethylaniline monooxygenase [N-oxide-forming] 5 is an enzyme in humans encoded by the FMO5 gene.
Metabolic N-oxidation of the diet-derived amino-trimethylamine (TMA) is mediated by flavin-containing monooxygenase and is subject to an inherited FMO3 polymorphism in man resulting in a small subpopulation with reduced TMA N-oxidation capacity resulting in fish odor syndrome Trimethylaminuria. Three forms of the enzyme, FMO1 found in fetal liver, FMO2 found in adult liver, and FMO3 are encoded by genes clustered in the 1q23-q25 region. Flavin-containing monooxygenases are NADPH-dependent flavoenzymes that catalyzes the oxidation of soft nucleophilic heteroatom centers in drugs, pesticides, and xenobiotics.