TLR6
Sign in to saveAlso known as CD286, toll like receptor 6
protein-coding gene in the species Homo sapiens
Gene data
TLR6- Name
- toll like receptor 6
- Type
- protein-coding
- Position
- 38,822,897–38,856,901 (−)
- Aliases
- CD286
- Ensembl
- ENSG00000174130
- RefSeq RNA
- NM_001394553.1, NM_006068.5, XM_005262637.6, XM_011513613.4, XM_024453873.2
- RefSeq protein
- NP_001381482.1, NP_006059.2, XP_005262694.1, XP_011511915.1, XP_024309641.1
The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor functionally interacts with toll-like receptor 2 to mediate cellular response to bacterial lipoproteins. A Ser249Pro polymorphism in the extracellular domain of the encoded protein may be associated with an increased of asthma is some populations.[provided by RefSeq, Jan 2011].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
toll like receptor 6
- Symbol
- TLR6
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 4:38,822,897-38,856,901
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
Show 5 more facts
- HomoloGene ID
- 21223
- exact match
- identifiers.org/ncbigene/10333
- genomic end
- 38858438
- genomic start
- 38822897
- cytogenetic location
- 4p14
Sources (4)
via Wikidata · CC0