TLR5

Also known as MELIOS, SLE1, SLEB1, TIL3, toll like receptor 5

protein-coding gene in the species Homo sapiens

Gene data

TLR5

Name: toll like receptor 5
Type: protein-coding
Aliases: MELIOS, SLE1, SLEB1, TIL3

This gene encodes a member of the toll-like receptor (TLR) family, which plays a fundamental role in pathogen recognition and activation of innate immune responses. These receptors recognize distinct pathogen-associated molecular patterns that are expressed on infectious agents. The protein encoded by this gene recognizes bacterial flagellin, the principal component of bacterial flagella and a virulence factor. The activation of this receptor mobilizes the nuclear factor NF-kappaB, which in turn activates a host of inflammatory-related target genes. Mutations in this gene have been associated with both resistance and susceptibility to systemic lupus erythematosus, and susceptibility to Legionnaire disease.[provided by RefSeq, Dec 2009].

via MyGene.info