LY96
Sign in to saveAlso known as ESOP-1, MD-2, MD2, ly-96, lymphocyte antigen 96
protein-coding gene in the species Homo sapiens
Gene data
LY96- Name
- lymphocyte antigen 96
- Type
- protein-coding
- Position
- 73,991,392–74,029,079 (+)
- Aliases
- ESOP-1, MD-2, MD2, ly-96
- Ensembl
- ENSG00000154589
- RefSeq RNA
- NM_001195797.2, NM_015364.5, XM_011517508.3, XM_017013299.2, XM_017013300.2
- RefSeq protein
- NP_001182726.1, NP_056179.4, XP_011515810.1, XP_016868788.1, XP_016868789.1
This gene encodes a protein which associates with toll-like receptor 4 on the cell surface and confers responsiveness to lipopolysaccyaride (LPS), thus providing a link between the receptor and LPS signaling. Studies of the mouse ortholog suggest that this gene may be involved in endotoxin neutralization. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2010].
Gene Ontology
Biological process
pattern recognition receptor signaling pathwaytoll-like receptor signaling pathwaycellular defense responsecell surface receptor signaling pathwaylipopolysaccharide-mediated signaling pathwaypositive regulation of lipopolysaccharide-mediated signaling pathwayresponse to lipopolysaccharideresponse to lipopolysaccharide
Molecular function
Pathways
NF-kappa B signaling pathway - Homo sapiens (human)Toll-like receptor signaling pathway - Homo sapiens (human)Salmonella infection - Homo sapiens (human)Pertussis - Homo sapiens (human)Toxoplasmosis - Homo sapiens (human)Lipid and atherosclerosis - Homo sapiens (human)ApoptosisER-Phagosome pathwayAntigen processing-Cross presentationAdaptive Immune System
via MyGene.info
Gene · Ensembl
lymphocyte antigen 96
- Symbol
- LY96
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 8:73,991,346-74,032,658
- Strand
- Forward (+)
- Assembly
- GRCh38
View on Ensembl →
via Ensembl · EMBL-EBI
Wikidata facts
- Image
- Protein LY96 PDB 1T2Z.png
Show 5 more facts
- HomoloGene ID
- 9109
- exact match
- identifiers.org/ncbigene/23643
- genomic end
- 74029079
- genomic start
- 73991392
- cytogenetic location
- 8q21.11
Sources (4)
via Wikidata · CC0
Connections
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Q180686
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Ensembl genome database project
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LBP
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Wikidata
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bibcode
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macrophage
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human genome
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Q229883
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base pair
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Medical Subject Headings
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locus
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gene expression
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Online Mendelian Inheritance in Man
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Protein Data Bank
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lipopolysaccharide
Entity