TNFRSF10B
Sign in to saveAlso known as CD262, DR5, KILLER, KILLER/DR5, TRAIL-R2, TRAILR2, TRICK2, TRICK2A
protein-coding gene in the species Homo sapiens
In the Vinony graph
Within Vinony's link graph, TNFRSF10B is referenced by 447 other articles, and connects out to PubMed, interferon gamma and Ensembl genome database project.
It is catalogued under topics including Clusters of differentiation, Genes on human chromosome 8 and TNF receptor family.
Its subject is documented across 8 Wikipedia language editions.
Gene data
TNFRSF10B- Name
- TNF receptor superfamily member 10b
- Type
- protein-coding
- Position
- 23,020,133–23,069,121 (−)
- Aliases
- CD262, DR5, KILLER, KILLER/DR5, TRAIL-R2, TRAILR2, TRICK2, TRICK2A, TRICK2B, TRICKB
- Ensembl
- ENSG00000120889
- RefSeq RNA
- NM_003842.5, NM_147187.3, NR_027140.2
- RefSeq protein
- NP_003833.4, NP_671716.2
The protein encoded by this gene is a member of the TNF-receptor superfamily, and contains an intracellular death domain. This receptor can be activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL/APO-2L), and transduces an apoptosis signal. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. Two transcript variants encoding different isoforms and one non-coding transcript have been found for this gene. [provided by RefSeq, Mar 2009].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
TNF receptor superfamily member 10b
- Symbol
- TNFRSF10B
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 8:23,020,133-23,069,121
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
- Image
- Protein TNFRSF10B PDB 1d0g.png
Show 8 more facts
- HomoloGene ID
- 117702
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/8795
- genomic end
- 23069031
- genomic start
- 22877646
- chromosome
- human chromosome 8
- cytogenetic location
- 8p21.3
- expressed in
- tibia
Sources (4)
via Wikidata · CC0