CRKL
Sign in to saveAlso known as CRK like proto-oncogene, adaptor protein
Crk-like protein is a protein that in humans is encoded by the CRKL gene.
In the Vinony graph
Within Vinony's link graph, CRKL is referenced by 36 other articles, and connects out to PubMed, Ensembl genome database project and protein.
It is catalogued under the topic Genes on human chromosome 22.
Its subject is documented across 6 Wikipedia language editions.
Gene data
CRKL- Name
- CRK like proto-oncogene, adaptor protein
- Type
- protein-coding
- Position
- 20,917,353–20,953,747 (+)
- Ensembl
- ENSG00000099942
- RefSeq RNA
- NM_005207.4, NR_156180.2
- RefSeq protein
- NP_005198.1
This gene encodes a protein kinase containing SH2 and SH3 (src homology) domains which has been shown to activate the RAS and JUN kinase signaling pathways and transform fibroblasts in a RAS-dependent fashion. It is a substrate of the BCR-ABL tyrosine kinase, plays a role in fibroblast transformation by BCR-ABL, and may be oncogenic.[provided by RefSeq, Jan 2009].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
CRK like proto-oncogene, adaptor protein
- Symbol
- CRKL
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 22:20,917,353-20,953,747
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
- Image
- Protein CRKL PDB 2bzx.png
Show 8 more facts
- HomoloGene ID
- 38021
- genomic end
- 21308037
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/1399
- genomic start
- 20917407
- chromosome
- human chromosome 22
- cytogenetic location
- 22q11.21
- expressed in
- cerebellar vermis
Sources (4)
via Wikidata · CC0
~1 min read
Encyclopedic overview
6 sectionsContents
- Function
- Interactions
- See also
- References
- Further reading
- External links
Crk-like protein is a protein that in humans is encoded by the CRKL gene.
== Function ==
Excerpted from Wikipedia’s “CRKL” article, available under the CC BY-SA 4.0 licence.