STAT5A
Sign in to saveAlso known as MGF, STAT5, signal transducer and activator of transcription 5A
Signal transducer and activator of transcription 5A is a protein that in humans is encoded by the STAT5A gene. STAT5A orthologs have been identified in several placentals for which complete genome data are available.
Gene data
STAT5A- Name
- signal transducer and activator of transcription 5A
- Type
- protein-coding
- Position
- 42,287,547–42,311,943 (+)
- Aliases
- MGF, STAT5
- Ensembl
- ENSG00000126561
- RefSeq RNA
- NM_001288718.2, NM_001288719.2, NM_001288720.2, NM_001411103.1, NM_003152.4
- RefSeq protein
- NP_001275647.1, NP_001275648.1, NP_001275649.1, NP_001398032.1, NP_003143.2
The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated by, and mediates the responses of many cell ligands, such as IL2, IL3, IL7 GM-CSF, erythropoietin, thrombopoietin, and different growth hormones. Activation of this protein in myeloma and lymphoma associated with a TEL/JAK2 gene fusion is independent of cell stimulus and has been shown to be essential for tumorigenesis. The mouse counterpart of this gene is found to induce the expression of BCL2L1/BCL-X(L), which suggests the antiapoptotic function of this gene in cells. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2013].
Gene Ontology
Biological process
Molecular function
Cellular component
Pathways
via MyGene.info
Gene · Ensembl
signal transducer and activator of transcription 5A
- Symbol
- STAT5A
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 17:42,287,547-42,311,943
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Image
- Protein STAT5A PDB 1y1u.png
Show 5 more facts
- HomoloGene ID
- 20680
- exact match
- identifiers.org/ncbigene/6776
- genomic end
- 40463961
- genomic start
- 40439565
- cytogenetic location
- 17q21.2
Sources (4)
via Wikidata · CC0
~5 min read
Article
10 sectionsContents
- Structure
- Function
- STAT5a and cancer
- Prostate Cancer
- Breast Cancer
- Therapeutic Treatment Approaches
- Interactions
- See also
- References
- Further reading
Signal transducer and activator of transcription 5A is a protein that in humans is encoded by the STAT5A gene. STAT5A orthologs have been identified in several placentals for which complete genome data are available.
== Structure == STAT5a shares the same six functional domains as the other members of the STAT family. It contains 20 amino acids unique to its C-terminal domain and is 96% similar to its homolog, STAT5b. The six functional domains and their corresponding amino acid positions are as follows: N-Terminal domain (aa1-144): stabilized interactions to form tetramers Coiled-coil domain (aa145-330): interacts with chaperones and facilitates protein-protein interactions for transcriptional regulation DNA binding domain (aa331-496): permits binding to consensus gamma-interferon activation sequence (GAS) Linker domain (aa497-592): stabilizes DNA binding Src Homology 2 domain (aa593-685): mediates receptor-specific recruitment and STAT dimerization via phosphorylated tyrosine residue Transcriptional activation domain (aa702-794): interacts with critical co-activators In addition to the six functional domains, specific amino acids have been identified as key mediators of STAT5a function. Phosphorylation of tyrosine 694 and glycosylation of threonine 92 are important for STAT5a activity. Mutation of serine 710 to phenylalanine results in constitutive activation.