STAT5
Sign in to saveAlso known as STAT5a/5b, IPR035858, STAT-5, STAT5 Transcription Factor
Signal transducer and activator of transcription 5 (STAT5) refers to two highly related proteins, STAT5A and STAT5B, which are part of the seven-membered STAT family of proteins. Though STAT5A and STAT5B are encoded by separate genes, the proteins are 90% identical at the amino acid level. STAT5 proteins are involved in cytosolic signalling and in mediating the expression of specific genes. Aberrant STAT5 activity has been shown to be closely connected to a wide range of human cancers, and silencing this aberrant activity is an area of active research in medicinal chemistry.
Research
8,149 papers- STAT5 in Cancer and Immunity.Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research · 2016
- Hyperactive STAT5 hijacks T cell receptor signaling and drives immature T cell acute lymphoblastic leukemia.The Journal of clinical investigation · 2024
- Genomic Mutations of the STAT5 Transcription Factor Are Associated with Human Cancer and Immune Diseases.International journal of molecular sciences · 2022
- Jak2/Stat5 signaling in mammogenesis, breast cancer initiation and progression.Journal of mammary gland biology and neoplasia · 2008
- STAT5 signaling in sexually dimorphic gene expression and growth patterns.American journal of human genetics · 1999
via PubMed
Wikidata facts
- Image
- Protein STAT5A PDB 1y1u.png
via Wikidata · CC0
~5 min read
Article
4 sectionsContents
- Activation and function
- STAT5 and cancer
- Treatment approaches
- References
Signal transducer and activator of transcription 5 (STAT5) refers to two highly related proteins, STAT5A and STAT5B, which are part of the seven-membered STAT family of proteins. Though STAT5A and STAT5B are encoded by separate genes, the proteins are 90% identical at the amino acid level. STAT5 proteins are involved in cytosolic signalling and in mediating the expression of specific genes. Aberrant STAT5 activity has been shown to be closely connected to a wide range of human cancers, and silencing this aberrant activity is an area of active research in medicinal chemistry.
== Activation and function ==