STAT5B

Name

signal transducer and activator of transcription 5B

Type

protein-coding

Position

42,199,176–42,288,633 (−)

Aliases

GHISID2, STAT5

Ensembl

ENSG00000173757

RefSeq RNA

NM_012448.4, XM_005257626.5, XM_017024977.2, XM_024450897.2, XM_024450898.2

RefSeq protein

NP_036580.2, XP_005257683.1, XP_016880466.1, XP_024306665.1, XP_024306666.1

The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein mediates the signal transduction triggered by various cell ligands, such as IL2, IL4, CSF1, and different growth hormones. It has been shown to be involved in diverse biological processes, such as TCR signaling, apoptosis, adult mammary gland development, and sexual dimorphism of liver gene expression. This gene was found to fuse to retinoic acid receptor-alpha (RARA) gene in a small subset of acute promyelocytic leukemias (APLL). The dysregulation of the signaling pathways mediated by this protein may be the cause of the APLL. [provided by RefSeq, Jul 2008].

via MyGene.info

Gene · Ensembl

signal transducer and activator of transcription 5B

Symbol

STAT5B

Biotype

Protein coding

Organism

Homo sapiens

Location

17:42,199,176-42,288,633

Strand

Reverse (−)

Assembly

GRCh38

Wikidata facts

Image

Protein STAT5B PDB 1y1u.png

via Wikidata · CC0