FLT3LG
Sign in to saveAlso known as FL, FLT3L, fms related tyrosine kinase 3 ligand, FLG3L, fms related receptor tyrosine kinase 3 ligand
protein-coding gene in the species Homo sapiens
Gene data
FLT3LG- Name
- fms related receptor tyrosine kinase 3 ligand
- Type
- protein-coding
- Position
- 49,474,150–49,486,233 (+)
- Aliases
- FL, FLG3L, FLT3L, IMD125
- Ensembl
- ENSG00000090554
- RefSeq RNA
- NM_001204502.2, NM_001204503.2, NM_001278637.2, NM_001278638.2, NM_001459.4
- RefSeq protein
- NP_001191431.1, NP_001191432.1, NP_001265566.1, NP_001265567.1, NP_001450.2
Dendritic cells (DCs) provide the key link between innate and adaptive immunity by recognizing pathogens and priming pathogen-specific immune responses. FLT3LG controls the development of DCs and is particularly important for plasmacytoid DCs and CD8 (see MIM 186910)-positive classical DCs and their CD103 (ITGAE; MIM 604682)-positive tissue counterparts (summary by Sathaliyawala et al., 2010 [PubMed 20933441]).[supplied by OMIM, Jan 2011].
Gene Ontology
Biological process
Molecular function
Pathways
MAPK signaling pathway - Homo sapiens (human)Ras signaling pathway - Homo sapiens (human)PI3K-Akt signaling pathway - Homo sapiens (human)Hematopoietic cell lineage - Homo sapiens (human)Pathways in cancer - Homo sapiens (human)PI3K CascadeIRS-mediated signallingPIP3 activates AKT signalingCytokine Signaling in Immune systemCytokine Signaling in Immune system
via MyGene.info
Gene · Ensembl
fms related receptor tyrosine kinase 3 ligand
- Symbol
- FLT3LG
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 19:49,474,150-49,486,233
- Strand
- Forward (+)
- Assembly
- GRCh38
View on Ensembl →
via Ensembl · EMBL-EBI