FLT3

Also known as CD135, FLK-2, FLK2, STK1, fms related tyrosine kinase 3, fms related receptor tyrosine kinase 3

Cluster of differentiation antigen 135 (CD135) also known as fms like tyrosine kinase 3 (FLT-3 with fms standing for "feline McDonough sarcoma"), receptor-type tyrosine-protein kinase FLT3, or fetal liver kinase-2 (Flk2) is a protein that in humans is encoded by the FLT3 gene. FLT3 is a cytokine receptor which belongs to the receptor tyrosine kinase class III. CD135 is the receptor for the cytokine Flt3 ligand (FLT3L).

Gene data

FLT3

Name: fms related receptor tyrosine kinase 3
Type: protein-coding
Position: 28,003,274–28,100,592 (−)
Aliases: CD135, FLK-2, FLK2, STK1
Ensembl: ENSG00000122025
RefSeq RNA: NM_001445917.1, NM_004119.3, NR_130706.2, XM_011535015.3, XM_011535018.3
RefSeq protein: NP_001432846.1, NP_004110.2, XP_011533317.1, XP_011533320.1, XP_016875975.1

This gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. This receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates multiple cytoplasmic effector molecules in pathways involved in apoptosis, proliferation, and differentiation of hematopoietic cells in bone marrow. Mutations that result in the constitutive activation of this receptor result in acute myeloid leukemia and acute lymphoblastic leukemia. [provided by RefSeq, Jan 2015].

Gene Ontology

Biological process

leukocyte homeostasis myeloid progenitor cell differentiation pro-B cell differentiation cell surface receptor signaling pathway cell surface receptor protein tyrosine kinase signaling pathway cell surface receptor protein tyrosine kinase signaling pathway cell surface receptor protein tyrosine kinase signaling pathway positive regulation of cell population proliferation

Molecular function

protein kinase activity protein tyrosine kinase activity protein tyrosine kinase activity transmembrane receptor protein tyrosine kinase activity transmembrane receptor protein tyrosine kinase activity transmembrane receptor protein tyrosine kinase activity transmembrane signaling receptor activity cytokine receptor activity

Cellular component

endoplasmic reticulum lumen plasma membrane plasma membrane endosome membrane membrane protein-containing complex signaling receptor complex

Pathways

MAPK signaling pathway - Homo sapiens (human)Ras signaling pathway - Homo sapiens (human)PI3K-Akt signaling pathway - Homo sapiens (human)Hematopoietic cell lineage - Homo sapiens (human)Pathways in cancer - Homo sapiens (human)Transcriptional misregulation in cancer - Homo sapiens (human)Acute myeloid leukemia - Homo sapiens (human)Central carbon metabolism in cancer - Homo sapiens (human)PI3K Cascade IRS-mediated signalling

via MyGene.info

Gene · Ensembl

fms related receptor tyrosine kinase 3

Symbol: FLT3
Biotype: Protein coding
Organism: Homo sapiens
Location: 13:28,003,274-28,100,592
Strand: Reverse (−)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Show 5 more facts

HomoloGene ID: 3040
exact match: identifiers.org/ncbigene/2322
genomic end: 28674729
genomic start: 28577411
cytogenetic location: 13q12.2

Sources (5)

via Wikidata · CC0

~5 min read

Article

10 sections

Contents

Structure
Function
Clinical significance
Cell surface marker
Role in cancer
FLT3 inhibitors
See also
References
Further reading
External links

It is expressed on the surface of many hematopoietic progenitor cells. Signalling of FLT3 is important for the normal development of haematopoietic stem cells and progenitor cells.