sunitinib
Sunitinib, sold under the brand name Sutent, is an anti-cancer medication. It is a small-molecule, multi-targeted receptor tyrosine kinase (RTK) inhibitor that was approved by the FDA for the treatment of renal cell carcinoma (RCC) and imatinib-resistant gastrointestinal stromal tumor (GIST) in January 2006. Sunitinib was the first cancer drug simultaneously approved for two different indications.
Chemical data
- Formula
- C22H27FN4O2
- Molecular weight
- 398.5 g/mol
- IUPAC name
- N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fluoro-2-oxo-1H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide
- SMILES
- CCN(CC)CCNC(=O)C1=C(NC(=C1C)/C=C\2/C3=C(C=CC(=C3)F)NC2=O)C
- InChIKey
- WINHZLLDWRZWRT-ATVHPVEESA-N
- XLogP
- 2.6
- Polar surface area
- 77.2 Ų
- H-bond donors
- 3
- H-bond acceptors
- 4
- Formal charge
- 0
via PubChem
Research
8,400 papersArticle
21 sectionsContents
- Medical uses
- Gastrointestinal stromal tumor
- Meningioma
- Aggressive fibromatosis
- Pancreatic neuroendocrine tumors
- Renal cell carcinoma
- Mechanism of action
- History
- Side effects
- Interactions
- Society and culture
- Economics
- US
- UK
- AU
- Research
- Other solid tumors
- Leukemia
- Unsuccessful trials
- References
- External links
Sunitinib, sold under the brand name Sutent, is an anti-cancer medication. It is a small-molecule, multi-targeted receptor tyrosine kinase (RTK) inhibitor that was approved by the FDA for the treatment of renal cell carcinoma (RCC) and imatinib-resistant gastrointestinal stromal tumor (GIST) in January 2006. Sunitinib was the first cancer drug simultaneously approved for two different indications.
As of August 2021, sunitinib is available as a generic medicine in the US.
Connections
Categories
Chemical articles with multiple CAS registry numbersChemical articles with multiple PubChem CIDsChemicals using indexlabelsDiethylamino compoundsDrugboxes which contain changes to verified fieldsDrugboxes which contain changes to watched fieldsDrugs developed by PfizerDrugs with non-standard legal statusFluoroarenesIndolesMultiple chemicals in Infobox drug