CBX5

Also known as HEL25, HP1, HP1A, chromobox 5

protein-coding gene in the species Homo sapiens

Gene data

CBX5

Name: chromobox 5
Type: protein-coding
Position: 54,230,942–54,280,133 (−)
Aliases: HEL25, HP1, HP1A, HP1alpha
Ensembl: ENSG00000094916
RefSeq RNA: NM_001127321.1, NM_001127322.1, NM_012117.3
RefSeq protein: NP_001120793.1, NP_001120794.1, NP_036249.1

This gene encodes a highly conserved nonhistone protein, which is a member of the heterochromatin protein family. The protein is enriched in the heterochromatin and associated with centromeres. The protein has a single N-terminal chromodomain which can bind to histone proteins via methylated lysine residues, and a C-terminal chromo shadow-domain (CSD) which is responsible for the homodimerization and interaction with a number of chromatin-associated nonhistone proteins. The encoded product is involved in the formation of functional kinetochore through interaction with essential kinetochore proteins. The gene has a pseudogene located on chromosome 3. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008].