CBX3

Also known as HECH, HP1-GAMMA, HP1Hs-gamma, chromobox 3

Chromobox protein homolog 3 is a protein that is encoded by the CBX3 gene in humans.

Gene data

CBX3

Name: chromobox 3
Type: protein-coding
Position: 26,200,568–26,213,607 (+)
Aliases: HECH, HP1-GAMMA, HP1Hs-gamma, HP1gamma
Ensembl: ENSG00000122565
RefSeq RNA: NM_001410866.1, NM_007276.5, NM_016587.4, XM_005249611.5, XM_054357182.1
RefSeq protein: NP_001397795.1, NP_009207.2, NP_057671.2, XP_005249668.1, XP_054213157.1

At the nuclear envelope, the nuclear lamina and heterochromatin are adjacent to the inner nuclear membrane. The protein encoded by this gene binds DNA and is a component of heterochromatin. This protein also can bind lamin B receptor, an integral membrane protein found in the inner nuclear membrane. The dual binding functions of the encoded protein may explain the association of heterochromatin with the inner nuclear membrane. This protein binds histone H3 tails methylated at Lys-9 sites. This protein is also recruited to sites of ultraviolet-induced DNA damage and double-strand breaks. Two transcript variants encoding the same protein but differing in the 5' UTR, have been found for this gene.[provided by RefSeq, Mar 2011].

Pathways

Shigellosis - Homo sapiens (human)Epigenetic regulation of gene expression Generic Transcription Pathway ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression Chromatin organization Chromatin organization Positive epigenetic regulation of rRNA expression RNA Polymerase I Promoter Escape RNA Polymerase II Transcription RNA Polymerase I Transcription

via MyGene.info

Gene · Ensembl

chromobox 3

Symbol: CBX3
Biotype: Protein coding
Organism: Homo sapiens
Location: 7:26,200,568-26,213,607
Strand: Forward (+)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of: gene
Image: Protein CBX3 PDB 2L11.png

Show 8 more facts

HomoloGene ID: 40583
found in taxon: Homo sapiens
exact match: identifiers.org/ncbigene/11335
genomic end: 26213607
genomic start: 26240782
chromosome: human chromosome 7
cytogenetic location: 7p15.2
expressed in: endometrium

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Encyclopedic overview

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Chromobox protein homolog 3 is a protein that is encoded by the CBX3 gene in humans.

At the nuclear envelope, the nuclear lamina and heterochromatin are adjacent to the inner nuclear membrane. The protein encoded by this gene binds DNA and is a component of heterochromatin. This protein also can bind lamin B receptor, an integral membrane protein found in the inner nuclear membrane. The dual binding functions of the encoded protein may explain the association of heterochromatin with the inner nuclear membrane. Two transcript variants encoding the same protein but differing in the 5' UTR, have been found for this gene.

Excerpted from Wikipedia’s “CBX3” article, available under the CC BY-SA 4.0 licence.