CLK2

Also known as CDC like kinase 2

Dual specificity protein kinase CLK2 is an enzyme that in humans is encoded by the CLK2 gene.

In the Vinony graph

Within Vinony's link graph, CLK2 is referenced by 5 other articles, and connects out to PubMed, human chromosome 1 and Ensembl genome database project.

It is catalogued under the topic Genes on human chromosome 1.

Its subject is documented across 4 Wikipedia language editions.

Gene data

CLK2

Name: CDC like kinase 2
Type: protein-coding
Position: 155,262,747–155,278,491 (−)
Ensembl: ENSG00000176444
RefSeq RNA: NM_001291.2, NM_001294338.2, NM_001294339.2, NM_001363704.2, NM_003993.4
RefSeq protein: NP_001281267.1, NP_001281268.1, NP_001350633.1, NP_003984.2, XP_011507445.1

This gene encodes a dual specificity protein kinase that phosphorylates serine/threonine and tyrosine-containing substrates. Activity of this protein regulates serine- and arginine-rich (SR) proteins of the spliceosomal complex, thereby influencing alternative transcript splicing. Chromosomal translocations have been characterized between this locus and the PAFAH1B3 (platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa)) gene on chromosome 19, resulting in the production of a fusion protein. Note that this gene is distinct from the TELO2 gene (GeneID:9894), which shares the CLK2 alias, but encodes a protein that is involved in telomere length regulation. There is a pseudogene for this gene on chromosome 7. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014].