MAP3K2
Sign in to saveAlso known as MEKK2, MEKK2B, mitogen-activated protein kinase kinase kinase 2
Mitogen-Activated Protein Kinase Kinase Kinase 2 also known as MEKK2 (MEK/ERK Kinase 2) is an enzyme that in humans is encoded by the MAP3K2 gene.
Gene data
MAP3K2- Name
- mitogen-activated protein kinase kinase kinase 2
- Type
- protein-coding
- Aliases
- MEKK2, MEKK2B
The protein encoded by this gene is a member of serine/threonine protein kinase family. This kinase preferentially activates other kinases involved in the MAP kinase signaling pathway. This kinase has been shown to directly phosphorylate and activate Ikappa B kinases, and thus plays a role in NF-kappa B signaling pathway. This kinase has also been found to bind and activate protein kinase C-related kinase 2, which suggests its involvement in a regulated signaling process. [provided by RefSeq, Jul 2008].
via MyGene.info
Gene · Ensembl
mitogen-activated protein kinase kinase kinase 2
- Symbol
- MAP3K2
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 2:127,298,668-127,388,465
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Image
- Protein MAP3K2 PDB 2cu1.png
Show 5 more facts
- HomoloGene ID
- 74576
- exact match
- identifiers.org/ncbigene/10746
- genomic end
- 128146041
- genomic start
- 127298668
- cytogenetic location
- 2q14.3
Sources (4)
via Wikidata · CC0
~1 min read
Article
5 sectionsContents
- Function
- Activation
- Interactions
- References
- Further reading
Mitogen-Activated Protein Kinase Kinase Kinase 2 also known as MEKK2 (MEK/ERK Kinase 2) is an enzyme that in humans is encoded by the MAP3K2 gene.
== Function ==