EIF2AK3
Sign in to saveAlso known as PEK, PERK, WRS, eukaryotic translation initiation factor 2 alpha kinase 3
Eukaryotic translation initiation factor 2-alpha kinase 3, also known as protein kinase R (PKR)-like endoplasmic reticulum kinase (PERK), is an enzyme that in humans is encoded by the EIF2AK3 gene.
Gene data
EIF2AK3- Name
- eukaryotic translation initiation factor 2 alpha kinase 3
- Type
- protein-coding
- Position
- 88,556,741–88,691,518 (−)
- Aliases
- PEK, PERK, WRS
- Ensembl
- ENSG00000172071
- RefSeq RNA
- NM_001313915.2, NM_004836.7, XM_047446428.1, XM_047446429.1, XM_047446430.1
- RefSeq protein
- NP_001300844.1, NP_004827.4, XP_047302384.1, XP_047302385.1, XP_047302386.1
The protein encoded by this gene phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2, leading to its inactivation, and thus to a rapid reduction of translational initiation and repression of global protein synthesis. This protein is thought to modulate mitochondrial function. It is a type I membrane protein located in the endoplasmic reticulum (ER), where it is induced by ER stress caused by malfolded proteins. Mutations in this gene are associated with Wolcott-Rallison syndrome. [provided by RefSeq, Sep 2015].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
eukaryotic translation initiation factor 2 alpha kinase 3
- Symbol
- EIF2AK3
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 2:88,556,741-88,691,518
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
~1 min read
Encyclopedic overview
6 sectionsContents
- Function
- Clinical significance
- Interactions
- Inhibitors
- References
- Further reading
Eukaryotic translation initiation factor 2-alpha kinase 3, also known as protein kinase R (PKR)-like endoplasmic reticulum kinase (PERK), is an enzyme that in humans is encoded by the EIF2AK3 gene.
== Function ==
Excerpted from Wikipedia’s “EIF2AK3” article, available under the CC BY-SA 4.0 licence.