TAB2

Also known as CHTD2, MAP3K7IP2, TAB-2, TGF-beta activated kinase 1/MAP3K7 binding protein 2, TGF-beta activated kinase 1 (MAP3K7) binding protein 2

Mitogen-activated protein kinase kinase kinase 7-interacting protein 2 is an enzyme that in humans is encoded by the MAP3K7IP2 gene.

Gene data

TAB2

Name: TGF-beta activated kinase 1 (MAP3K7) binding protein 2
Type: protein-coding
Aliases: CHTD2, MAP3K7IP2, TAB-2

The protein encoded by this gene is an activator of MAP3K7/TAK1, which is required for for the IL-1 induced activation of nuclear factor kappaB and MAPK8/JNK. This protein forms a kinase complex with TRAF6, MAP3K7 and TAB1, and it thus serves as an adaptor that links MAP3K7 and TRAF6. This protein, along with TAB1 and MAP3K7, also participates in the signal transduction induced by TNFSF11/RANKl through the activation of the receptor activator of NF-kappaB (TNFRSF11A/RANK), which may regulate the development and function of osteoclasts. Studies of the related mouse protein indicate that it functions to protect against liver damage caused by chemical stressors. Mutations in this gene cause congenital heart defects, multiple types, 2 (CHTD2). Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014].

via MyGene.info

Gene · Ensembl

TGF-beta activated kinase 1 (MAP3K7) binding protein 2

Symbol: TAB2
Biotype: Protein coding
Organism: Homo sapiens
Location: 6:149,218,641-149,411,901
Strand: Forward (+)
Assembly: GRCh38

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via Ensembl · EMBL-EBI

Wikidata facts

Image: Protein MAP3K7IP2 PDB 2dae.png

Show 5 more facts

HomoloGene ID: 9019
exact match: identifiers.org/ncbigene/23118
cytogenetic location: 6q25.1
genomic start: 149539777
genomic end: 149732749

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Mitogen-activated protein kinase kinase kinase 7-interacting protein 2 is an enzyme that in humans is encoded by the MAP3K7IP2 gene.

The protein encoded by this gene is an activator of MAP3K7/TAK1, which is required for the IL-1 induced activation of nuclear factor kappaB and MAPK8/JNK. This protein forms a kinase complex with TRAF6, MAP3K7 and TAB1, thus serves as an adaptor linking MAP3K7 and TRAF6. This protein, TAB1, and MAP3K7 also participate in the signal transduction induced by TNFSF11/RANKL through the activation of the receptor activator of NF-kappB (TNFRSF11A/RANK), which may regulate the development and function of osteoclasts. Mutations in MAP3K7IP2 have been associated with human congenital heart defects.