HDAC3

Name

histone deacetylase 3

Type

protein-coding

Position

141,620,778–141,636,867 (−)

Aliases

HD3, KDAC3, RPD3, RPD3-2

Ensembl

ENSG00000171720

RefSeq RNA

NM_001355039.2, NM_001355040.2, NM_001355041.2, NM_003883.4, NR_149164.2

RefSeq protein

NP_001341968.1, NP_001341969.1, NP_001341970.1, NP_003874.2

Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family. It has histone deacetylase activity and represses transcription when tethered to a promoter. It may participate in the regulation of transcription through its binding with the zinc-finger transcription factor YY1. This protein can also down-regulate p53 function and thus modulate cell growth and apoptosis. This gene is regarded as a potential tumor suppressor gene. [provided by RefSeq, Jul 2008].

via MyGene.info

Gene · Ensembl

histone deacetylase 3

Symbol

HDAC3

Biotype

Protein coding

Organism

Homo sapiens

Location

5:141,620,766-141,637,304

Strand

Reverse (−)

Assembly

GRCh38

• HDAC3 deficiency protects against acute lung injury by maintaining epithelial barrier integrity through preserving mitochondrial quality control.Redox biology · 2023
• HDAC3 aberration-incurred GPX4 suppression drives renal ferroptosis and AKI-CKD progression.Redox biology · 2023
• HDAC3 inhibition ameliorates ischemia/reperfusion-induced brain injury by regulating the microglial cGAS-STING pathway.Theranostics · 2020
• Kaempferol alleviates myocardial ischemia injury by reducing oxidative stress via the HDAC3-mediated Nrf2 signaling pathway.Journal of advanced research · 2025
• Arresting the bad seed: HDAC3 regulates proliferation of different microglia after ischemic stroke.Science advances · 2024

via PubMed

Wikidata facts

via Wikidata · CC0