Also known as C20orf32, CAS4, HEFL, HEPL, Cas scaffolding protein family member 4, Cas scaffold protein family member 4
Cas scaffolding protein family member 4 is a protein that in humans is encoded by the CASS4 gene.
Enables protein tyrosine kinase binding activity. Involved in several processes, including positive regulation of protein kinase B signaling; positive regulation of protein tyrosine kinase activity; and positive regulation of substrate adhesion-dependent cell spreading. Located in focal adhesion. Part of cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
via MyGene.info
Cas scaffolding protein family member 4 is a protein that in humans is encoded by the CASS4 gene.
== History and discovery == CASS4 (Crk associated substrate 4) is the fourth and last described member of the CAS protein family. CASS4 was detected by Singh et al. in 2008 following in silico screening of databases describing expressed sequence tags from an evolutionarily diverse group of organisms, using the CAS-related proteins (p130Cas, NEDD9/HEF1 and EFS) mRNAs as templates. Singh et al. subsequently cloned and characterized the CASS4 gene, originally assigning the name HEPL (HEF1-EFS-p130Cas-like) for similarity to the other three defined CAS genes. The official name was subsequently changed to CASS4 by the Human Genome Organization (HUGO) Gene Nomenclature Committee (HGNC).
Discovered by embedding cosine similarity (sentence-transformers MiniLM, 384-dim).