BCAR1

Name

BCAR1 scaffold protein, Cas family member

Type

protein-coding

Position

75,228,181–75,268,053 (−)

Aliases

CAS, CAS1, CASS1, CRKAS, P130Cas

Ensembl

ENSG00000050820

RefSeq RNA

NM_001170714.3, NM_001170715.3, NM_001170716.3, NM_001170717.3, NM_001170718.3

RefSeq protein

NP_001164185.1, NP_001164186.1, NP_001164187.1, NP_001164188.1, NP_001164189.1

The protein encoded by this gene is a member of the Crk-associated substrate (CAS) family of scaffold proteins, characterized by the presence of multiple protein-protein interaction domains and many serine and tyrosine phosphorylation sites. The encoded protein contains a Src-homology 3 (SH3) domain, a proline-rich domain, a substrate domain which contains 15 repeat of the YxxP consensus phosphorylation motif for Src family kinases, a serine-rich domain, and a bipartite Src-binding domain, which can bind both SH2 and SH3 domains. This adaptor protein functions in multiple cellular pathways, including in cell motility, apoptosis and cell cycle control. Dysregulation of this gene can have a wide range of effects, affecting different pathways, including cardiac development, vascular smooth muscle cells, liver and kidney function, endothelial migration, and cancer. [provided by RefSeq, Sep 2017].

via MyGene.info

Gene · Ensembl

BCAR1 scaffold protein, Cas family member

Symbol

BCAR1

Biotype

Protein coding

Organism

Homo sapiens

Location

16:75,228,181-75,268,053

Strand

Reverse (−)

Assembly

GRCh38

Wikidata facts

Image

Protein BCAR1 PDB 1wyx.png

via Wikidata · CC0