PRKCB
Sign in to saveAlso known as PKC-beta, PKCB, PRKCB1, PRKCB2, protein kinase C beta, PKCbeta, PKCI(2)
Protein kinase C beta type is an enzyme that in humans is encoded by the PRKCB gene.
Gene data
PRKCB- Name
- protein kinase C beta
- Type
- protein-coding
- Aliases
- PKC-beta, PKCB, PKCI(2), PKCbeta, PRKCB1, PRKCB2
Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This protein kinase has been reported to be involved in many different cellular functions, such as B cell activation, apoptosis induction, endothelial cell proliferation, and intestinal sugar absorption. Studies in mice also suggest that this kinase may also regulate neuronal functions and correlate fear-induced conflict behavior after stress. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008].
via MyGene.info
Gene · Ensembl
protein kinase C beta
- Symbol
- PRKCB
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 16:23,835,939-24,220,611
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Image
- Protein PRKCB1 PDB 1a25.png
Show 5 more facts
- HomoloGene ID
- 56424
- exact match
- identifiers.org/ncbigene/5579
- genomic end
- 24231932
- genomic start
- 23835983
- cytogenetic location
- 16p12.2-p12.1
via Wikidata · CC0
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Protein kinase C beta type is an enzyme that in humans is encoded by the PRKCB gene.
Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This protein kinase has been reported to be involved in many different cellular functions, such as B cell activation, apoptosis induction, endothelial cell proliferation, and intestinal sugar absorption. Studies in mice also suggest that this kinase may also regulate neuronal functions and correlate fear-induced conflict behavior after stress. Alternatively spliced transcript variants encoding distinct isoforms have been reported. This gene could be associated with autism.