DOCK2

Name

dedicator of cytokinesis 2

Type

protein-coding

Aliases

IMD40

The protein encoded by this gene belongs to the CDM protein family. It is specifically expressed in hematopoietic cells and is predominantly expressed in peripheral blood leukocytes. The protein is involved in remodeling of the actin cytoskeleton required for lymphocyte migration in response to chemokine signaling. It activates members of the Rho family of GTPases, for example RAC1 and RAC2, by acting as a guanine nucleotide exchange factor (GEF) to exchange bound GDP for free GTP. Mutations in this gene result in immunodeficiency 40 (IMD40), a combined form of immunodeficiency that affects T cell number and function, also with variable defects in B cell and NK cell function. [provided by RefSeq, May 2018].

via MyGene.info

Gene · Ensembl

dedicator of cytokinesis 2

Symbol

DOCK2

Biotype

Protein coding

Organism

Homo sapiens

Location

5:169,637,224-170,083,382

Strand

Forward (+)

Assembly

GRCh38

Wikidata facts

Image

Protein DOCK2 PDB 2RQR.png

via Wikidata · CC0