SIL1

Also known as BAP, MSS, ULG5, SIL1 nucleotide exchange factor

Nucleotide exchange factor SIL1 is a protein encoded in humans by the SIL1 gene.

Gene data

SIL1

Name: SIL1 nucleotide exchange factor
Type: protein-coding
Aliases: BAP, MSS, ULG5

This gene encodes a resident endoplasmic reticulum (ER), N-linked glycoprotein with an N-terminal ER targeting sequence, 2 putative N-glycosylation sites, and a C-terminal ER retention signal. This protein functions as a nucleotide exchange factor for another unfolded protein response protein. Mutations in this gene have been associated with Marinesco-Sjogren syndrome. Alternate transcriptional splice variants have been characterized. [provided by RefSeq, Jul 2008].

via MyGene.info

Gene · Ensembl

SIL1 nucleotide exchange factor

Symbol: SIL1
Biotype: Protein coding
Organism: Homo sapiens
Location: 5:138,886,914-139,293,557
Strand: Reverse (−)
Assembly: GRCh38

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via Ensembl · EMBL-EBI

Wikidata facts

Show 5 more facts

HomoloGene ID: 32544
exact match: identifiers.org/ncbigene/64374
genomic end: 138629246
genomic start: 138946724
cytogenetic location: 5q31.2

Sources (6)

via Wikidata · CC0

~5 min read

Article

7 sections

Contents

Discovery and expression
Structure and mechanism of nucleotide exchange
Tissue expression
Interactions
References
Further reading
External links

Nucleotide exchange factor SIL1 is a protein encoded in humans by the SIL1 gene.

This gene encodes a resident endoplasmic reticulum (ER) N-linked glycoprotein with an N-terminal ER targeting sequence, two putative N-glycosylation sites, and a C-terminal ER retention signal. This protein functions as a nucleotide exchange factor for another unfolded protein response protein. Mutations in this gene have been associated with Marinesco-Sjogren syndrome. Alternative transcriptional splice variants have been characterized.