FGD2

Also known as ZFYVE4, FYVE, RhoGEF and PH domain containing 2

FYVE, RhoGEF and PH domain-containing protein 2 (FGD2), also known as zinc finger FYVE domain-containing protein 4 (ZFYVE4), is a protein that in humans is encoded by the FGD2 gene.

Gene data

FGD2

Name: FYVE, RhoGEF and PH domain containing 2
Type: protein-coding
Position: 37,005,645–37,029,299 (+)
Aliases: ZFYVE4
Ensembl: ENSG00000146192
RefSeq RNA: NM_173558.4, XM_011514372.3, XM_011514373.3, XM_047418332.1, XM_047418333.1
RefSeq protein: NP_775829.2, XP_011512674.1, XP_011512675.1, XP_047274288.1, XP_047274289.1

The protein encoded by this gene belongs to a family of guanine nucleotide exchange factors (GEFs) which control cytoskeleton-dependent membrane rearrangements by activating the cell division cycle 42 (CDC42) protein. This gene is expressed in B lymphocytes, macrophages, and dendritic cells. The encoded protein may play a role in leukocyte signaling and vesicle trafficking in antigen-presenting cells in the immune system. [provided by RefSeq, Oct 2016].

Gene Ontology

Biological process

cytoskeleton organization cytoskeleton organization

Article

3 sections

Contents

See also
References
Further reading

FYVE, RhoGEF and PH domain-containing protein 2 (FGD2), also known as zinc finger FYVE domain-containing protein 4 (ZFYVE4), is a protein that in humans is encoded by the FGD2 gene.

It is a member of the FYVE, RhoGEF and PH domain containing family.