TSC complex subunit 1
Sign in to saveAlso known as tumor suppressor, tuberous sclerosis 1 protein, TSC1, truncated hemartin, hamartin
Tuberous sclerosis 1 (TSC1), also known as hamartin, is a protein that in humans is encoded by the TSC1 gene.
Protein · UniProt
Hamartin
- Gene
- TSC1
- Organism
- Homo sapiens (Human)
- Length
- 1,164 aa
- Molecular mass
- 129,767 Da
- Evidence
- 1: Evidence at protein level
Non-catalytic component of the TSC-TBC complex, a multiprotein complex that acts as a negative regulator of the canonical mTORC1 complex, an evolutionarily conserved central nutrient sensor that stimulates anabolic reactions and macromolecule biosynthesis to promote cellular biomass generation and growth (PubMed:12172553, PubMed:12271141, PubMed:12906785, PubMed:15340059, PubMed:24529379, PubMed:28215400). The TSC-TBC complex acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1 (PubMed:12906785, PubMed:15340059, Pub…
Swiss-Prot (reviewed) · via UniProt
Research
104 papers- Buddleoside alleviates nonalcoholic steatohepatitis by targeting the AMPK-TFEB signaling pathway.Autophagy · 2025
- How autophagy controls the intestinal epithelial barrier.Autophagy · 2022
- Emerging dimensions of autophagy in melanoma.Autophagy · 2024
- Targeting NPM1 Epigenetically Promotes Postinfarction Cardiac Repair by Reprogramming Reparative Macrophage Metabolism.Circulation · 2024
- Full-coverage regulations of autophagy by ROS: from induction to maturation.Autophagy · 2022
via PubMed
~1 min read
Article
7 sectionsContents
- Function
- Clinical significance
- Interactions
- See also
- References
- Further reading
- External links
Tuberous sclerosis 1 (TSC1), also known as hamartin, is a protein that in humans is encoded by the TSC1 gene.
== Function == TSC1 functions as a co-chaperone which inhibits the ATPase activity of the chaperone Hsp90 (heat shock protein-90) and decelerates its chaperone cycle. TSC1 functions as a facilitator of Hsp90 in chaperoning the kinase and non-kinase clients including TSC2, therefore preventing their ubiquitination and degradation in the proteasome. TSC1, TSC2 and TBC1D7 is a multi-protein complex also known as the TSC complex. This complex negatively regulates mTORC1 signaling by functioning as a GTPase-activating protein (GAP) for the small GTPase Rheb, an essential activator of mTORC1. The TSC complex has been implicated as a tumor suppressor.