TSC1
Sign in to saveAlso known as tumor suppressor, tuberous sclerosis 1 protein, truncated hemartin, hamartin
Tuberous sclerosis 1 (TSC1), also known as hamartin, is a protein that in humans is encoded by the TSC1 gene.
Protein · UniProt
Hamartin
- Gene
- TSC1
- Organism
- Homo sapiens (Human)
- Length
- 1,164 aa
- Molecular mass
- 129,767 Da
- Evidence
- 1: Evidence at protein level
Non-catalytic component of the TSC-TBC complex, a multiprotein complex that acts as a negative regulator of the canonical mTORC1 complex, an evolutionarily conserved central nutrient sensor that stimulates anabolic reactions and macromolecule biosynthesis to promote cellular biomass generation and growth (PubMed:12172553, PubMed:12271141, PubMed:12906785, PubMed:15340059, PubMed:24529379, PubMed:28215400). The TSC-TBC complex acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1 (PubMed:12906785, PubMed:15340059, Pub…
Swiss-Prot (reviewed) · via UniProt
Research
104 papers- Buddleoside alleviates nonalcoholic steatohepatitis by targeting the AMPK-TFEB signaling pathway.Autophagy · 2025
- How autophagy controls the intestinal epithelial barrier.Autophagy · 2022
- Emerging dimensions of autophagy in melanoma.Autophagy · 2024
- Targeting NPM1 Epigenetically Promotes Postinfarction Cardiac Repair by Reprogramming Reparative Macrophage Metabolism.Circulation · 2024
- Full-coverage regulations of autophagy by ROS: from induction to maturation.Autophagy · 2022
via PubMed
Wikidata facts
- Instance of
- protein
Show 2 more facts
- P352
- Ivanivka
- found in taxon
- Homo sapiens
via Wikidata · CC0