KIFBP
Sign in to saveAlso known as KBP, KIAA1279, TTC20, KIF1 binding protein, kinesin family binding protein, KIF1BP
KIF1-binding protein, also known as Kinesin binding protein(KBP), is a protein that in humans is encoded by the KIAA1279 gene. The interaction of KBP with Kif15 is necessary for the localization of Kif15 to the microtubule plus-end at the spindle equator. Interaction between Kif15 and KBP is essential for the perfect alignment of chromosomes at the metaphase plate, and any defect in their interaction leads to delay in chromosomal alignment during mitosis. Anything that perturb the interaction of KBP and Kif15 can block the cells at mitosis, and hence it can be therapeutically used to control K
Gene data
KIFBP- Name
- kinesin family binding protein
- Type
- protein-coding
- Aliases
- KBP, KIAA1279, KIF1BP, TTC20
This gene encodes a kinesin family member 1 binding protein that is characterized by two tetratrico peptide repeats. The encoded protein localizes to the mitochondria and may be involved in regulating transport of the mitochondria. Mutations in this gene are associated with Goldberg-Shprintzen megacolon syndrome. [provided by RefSeq, Mar 2010].
via MyGene.info
Gene · Ensembl
kinesin family binding protein
- Symbol
- KIFBP
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 10:68,988,732-69,043,544
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
Show 5 more facts
- HomoloGene ID
- 9223
- exact match
- identifiers.org/ncbigene/26128
- genomic end
- 70776738
- genomic start
- 68988803
- cytogenetic location
- 10q22.1
Sources (4)
via Wikidata · CC0
~1 min read
Article
5 sectionsContents
- Clinical significance
- Interactions
- References
- Further reading
- External links
KIF1-binding protein, also known as Kinesin binding protein(KBP), is a protein that in humans is encoded by the KIAA1279 gene. The interaction of KBP with Kif15 is necessary for the localization of Kif15 to the microtubule plus-end at the spindle equator. Interaction between Kif15 and KBP is essential for the perfect alignment of chromosomes at the metaphase plate, and any defect in their interaction leads to delay in chromosomal alignment during mitosis. Anything that perturb the interaction of KBP and Kif15 can block the cells at mitosis, and hence it can be therapeutically used to control Kif15 upregulated cancer cells.
== Clinical significance ==