CEP126
Sign in to saveAlso known as KIAA1377, centrosomal protein 126
Uncharacterized protein KIAA1377 is a protein that in humans is encoded by the KIAA1377 gene. Also known as Cep126, the protein has been shown to localize to the centrosome. Furthermore, it is found at pericentriolar satellites and the base of the primary cilium. Depleting Cep126 leads to dispersion of pericentriolar satellites, in turn disrupting microtubule organization at the mitotic spindle.
Gene data
CEP126- Name
- centrosomal protein 126
- Type
- protein-coding
- Aliases
- KIAA1377
Involved in cilium assembly; cytoplasmic microtubule organization; and mitotic spindle organization. Located in centrosome; ciliary base; and midbody. [provided by Alliance of Genome Resources, Apr 2022]
via MyGene.info
Gene · Ensembl
centrosomal protein 126
- Symbol
- CEP126
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 11:101,914,997-102,001,062
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
Show 5 more facts
- HomoloGene ID
- 28313
- exact match
- identifiers.org/ncbigene/57562
- genomic end
- 102001062
- genomic start
- 101915010
- cytogenetic location
- 11q22.1
Sources (4)
via Wikidata · CC0
~1 min read
Article
3 sectionsContents
- Clinical relevance
- References
- Further reading
Uncharacterized protein KIAA1377 is a protein that in humans is encoded by the KIAA1377 gene. Also known as Cep126, the protein has been shown to localize to the centrosome. Furthermore, it is found at pericentriolar satellites and the base of the primary cilium. Depleting Cep126 leads to dispersion of pericentriolar satellites, in turn disrupting microtubule organization at the mitotic spindle.
==Clinical relevance== Mutations in this gene have been found to cause monomelic amyotrophy.