CCAR2

Also known as DBC-1, DBC1, KIAA1967, NET35, p30 DBC, p30DBC, cell cycle and apoptosis regulator 2

KIAA1967, also known as Deleted in Breast Cancer 1, is a protein which in humans is encoded by the KIAA1967 gene.

Gene data

CCAR2

Name: cell cycle and apoptosis regulator 2
Type: protein-coding
Position: 22,604,629–22,620,964 (+)
Aliases: DBC-1, DBC1, KIAA1967, NET35, p30 DBC, p30DBC
Ensembl: ENSG00000158941
RefSeq RNA: NM_001363068.2, NM_001363069.2, NM_001393997.1, NM_021174.6, NM_199205.1
RefSeq protein: NP_001349997.1, NP_001349998.1, NP_001380926.1, NP_066997.3, XP_011542906.1

Enables RNA polymerase II complex binding activity and enzyme inhibitor activity. Involved in several processes, including regulation of cellular protein metabolic process; regulation of signal transduction; and regulation of transcription, DNA-templated. Located in several cellular components, including mitochondrial matrix; nucleoplasm; and spindle. Part of DBIRD complex. [provided by Alliance of Genome Resources, Apr 2022]

Gene Ontology

Biological process

regulation of DNA-templated transcription

Article

3 sections

Contents

Function
References
Further reading

KIAA1967, also known as Deleted in Breast Cancer 1, is a protein which in humans is encoded by the KIAA1967 gene.

== Function == Recent studies show that DBC1 is an inhibitor of the sirtuin-type deacetylase, SIRT1, which deacetylates histones and p53. DBC1 is likely to regulate the activity of SIRT1 or related deacetylases by sensing the soluble products or substrates of the NAD-dependent deacetylation reaction.