RTKN
Sign in to saveAlso known as rhotekin
Rhotekin is a protein that in humans is encoded by the RTKN gene.
In the Vinony graph
Vinony's link graph records 2 inbound references to RTKN, and connects out to PubMed, human chromosome 2 and Ensembl genome database project.
It is catalogued under the topic Genes on human chromosome 2.
Vinony links it to 5 Wikipedia language editions.
Gene data
RTKN- Name
- rhotekin
- Type
- protein-coding
- Aliases
- RTKN-1
This gene encodes a scaffold protein that interacts with GTP-bound Rho proteins. Binding of this protein inhibits the GTPase activity of Rho proteins. This protein may interfere with the conversion of active, GTP-bound Rho to the inactive GDP-bound form by RhoGAP. Rho proteins regulate many important cellular processes, including cytokinesis, transcription, smooth muscle contraction, cell growth and transformation. Dysregulation of the Rho signal transduction pathway has been implicated in many forms of cancer. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008].
via MyGene.info
Gene · Ensembl
rhotekin
- Symbol
- RTKN
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 2:74,424,131-74,442,422
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 7 more facts
- HomoloGene ID
- 7522
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/6242
- genomic end
- 74669549
- genomic start
- 74425835
- chromosome
- human chromosome 2
- cytogenetic location
- 2p13.1
Sources (4)
via Wikidata · CC0
~1 min read
Encyclopedic overview
2 sectionsContents
- References
- Further reading
Rhotekin is a protein that in humans is encoded by the RTKN gene.
This gene encodes a scaffold protein that interacts with GTP-bound Rho proteins. Binding of this protein inhibits the GTPase activity of Rho proteins. This protein may interfere with the conversion of active, GTP-bound Rho to the inactive GDP-bound form by RhoGAP. Rho proteins regulate many important cellular processes, including cytokinesis, transcription, smooth muscle contraction, cell growth and transformation. Dysregulation of the Rho signal transduction pathway has been implicated in many forms of cancer. Alternative splicing results in multiple transcript variants encoding different isoforms.
Excerpted from Wikipedia’s “RTKN” article, available under the CC BY-SA 4.0 licence.