Also known as ASYIP, HAP, NSPL2, NSPLII, RTN3-A1, reticulon 3
Reticulon-3 is a protein that in humans is encoded by the RTN3 gene.
This gene belongs to the reticulon family of highly conserved genes that are preferentially expressed in neuroendocrine tissues. This family of proteins interact with, and modulate the activity of beta-amyloid converting enzyme 1 (BACE1), and the production of amyloid-beta. An increase in the expression of any reticulon protein substantially reduces the production of amyloid-beta, suggesting that reticulon proteins are negative modulators of BACE1 in cells. Alternatively spliced transcript variants encoding different isoforms have been found for this gene, and pseudogenes of this gene are located on chromosomes 4 and 12. [provided by RefSeq, May 2012].
via MyGene.info
Reticulon-3 is a protein that in humans is encoded by the RTN3 gene.
The reticulons are a group of highly conserved genes with preferential expression in neuroendocrine tissues (see, e.g., RTN1; MIM 600865).[supplied by OMIM]
Discovered by embedding cosine similarity (sentence-transformers MiniLM, 384-dim).