TSN

Also known as BCLF-1, C3PO, RCHF1, REHF-1, TBRBP, TRSLN, translin

Translin is a DNA-binding protein that in humans is encoded by the TSN gene. Together with translin-associated factor X, translin forms the component 3 of promoter of RISC (C3PO) complex which facilitates endonucleolytic cleavage of the passenger strand during microRNA loading into the RNA-induced silencing complex (RISC).

In the Vinony graph

Vinony's link graph records 6 inbound references to TSN, and connects out to PubMed, human chromosome 2 and Ensembl genome database project.

It is catalogued under the topic Genes on human chromosome 2.

Vinony links it to 5 Wikipedia language editions.

Gene data

TSN

Name: translin
Type: protein-coding
Position: 121,737,103–121,767,871 (+)
Aliases: BCLF-1, C3PO, RCHF1, REHF-1, TBRBP, TRSLN
Ensembl: ENSG00000211460
RefSeq RNA: NM_001261401.2, NM_004622.3, NR_048556.2, NR_048557.2, NR_048558.2
RefSeq protein: NP_001248330.1, NP_004613.1

This gene encodes a DNA-binding protein which specifically recognizes conserved target sequences at the breakpoint junction of chromosomal translocations. Translin polypeptides form a multimeric structure that is responsible for its DNA-binding activity. Recombination-associated motifs and translin-binding sites are present at recombination hotspots and may serve as indicators of breakpoints in genes which are fused by translocations. These binding activities may play a crucial role in chromosomal translocation in lymphoid neoplasms. This protein encoded by this gene, when complexed with translin-associated protein X, also forms a Mg ion-dependent endoribonuclease that promotes RNA-induced silencing complex (RISC) activation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2012].