File:3a6p_xpo5_ran_miRNA.png · Wikimedia Commons · See Wikimedia Commons
microRNA
Sign in to saveAlso known as miRNA, microribonucleic acid, microRNAs
thumb|400px|Pre-miRNA instead of Pri-miRNA in the first point of mechanism. Diagram of microRNA (miRNA) action with mRNA thumb|400px|Examples of miRNA hairpins (stem-loops), with the mature miRNAs shown in red
Research
193,226 papers- Overview of microRNA biology.Seminars in liver disease · 2015
- MicroRNA-mediated gene regulation and the resilience of multicellular animals.Postepy biochemii · 2024
- Correlation between microRNA-21 expression and overweight/obesity.Folia medica · 2024
- Engineered microRNA therapeutics.The journal of the Royal College of Physicians of Edinburgh · 2014
- MicroRNA biomarkers of type 2 diabetes: evidence synthesis from meta-analyses and pathway modelling.Diabetologia · 2023
via PubMed
~50 min read
Encyclopedic overview
37 sectionsContents
- History
- Nomenclature
- Targets
- Biogenesis
- Transcription
- Nuclear processing
- Nuclear export
- Cytoplasmic processing
- Biogenesis in plants
- RNA-induced silencing complex
- Mode of silencing and regulatory loops
- Turnover
- Cellular functions
- Evolution
- Experimental detection and manipulation
- Human and animal diseases
- Inherited diseases
- Cancer
- DNA repair and cancer
- Heart disease
- miRNA-712
- Origin
- Mechanism
- Human homolog microRNA-205
- Kidney disease
- Nervous system
- Stroke
- Alcoholism
- Obesity
- Hemostasis
- Plants
- Viruses
- Target prediction
- See also
- References
- Further reading
- External links
thumb|400px|Pre-miRNA instead of Pri-miRNA in the first point of mechanism. Diagram of microRNA (miRNA) action with mRNA thumb|400px|Examples of miRNA hairpins (stem-loops), with the mature miRNAs shown in red
Micro ribonucleic acid (microRNA, miRNA, μRNA) are small, single-stranded, non-coding RNA molecules containing 21–23 nucleotides. Found in plants, animals, and even some viruses, miRNAs are involved in RNA silencing and post-transcriptional regulation of gene expression. miRNAs base-pair to complementary sequences in messenger RNA (mRNA) molecules, then silence said mRNA molecules by one or more of the following processes: Cleaving the mRNA strand into two pieces. Destabilizing the mRNA by shortening its poly(A) tail. Reducing translation of the mRNA into proteins.
Excerpted from Wikipedia’s “microRNA” article, available under the CC BY-SA 4.0 licence.