CASP2
Sign in to saveAlso known as CASP-2, ICH1, NEDD-2, NEDD2, PPP1R57, caspase 2
protein-coding gene in the species Homo sapiens
Gene data
CASP2- Name
- caspase 2
- Type
- protein-coding
- Position
- 143,288,215–143,307,696 (+)
- Aliases
- CASP-2, ICH1, MRT80, NEDD-2, NEDD2, PPP1R57
- Ensembl
- ENSG00000106144
- RefSeq RNA
- NM_001224.5, NM_032982.4, NM_032983.4, NM_032984.2
- RefSeq protein
- NP_001215.1, NP_116764.2, NP_116765.2
This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Caspases mediate cellular apoptosis through the proteolytic cleavage of specific protein substrates. The encoded protein may function in stress-induced cell death pathways, cell cycle maintenance, and the suppression of tumorigenesis. Increased expression of this gene may play a role in neurodegenerative disorders including Alzheimer's disease, Huntington's disease and temporal lobe epilepsy. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
caspase 2
- Symbol
- CASP2
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 7:143,288,215-143,307,696
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
- Image
- Protein CASP2 PDB 1pyo.png
Show 9 more facts
- HomoloGene ID
- 7254
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/835
- genomic end
- 143004789
- genomic start
- 142985308
- chromosome
- human chromosome 7
- cytogenetic location
- 7q34
- expressed in
- testicle
- Commons category
- Caspase 2
via Wikidata · CC0