BCL10

Name

BCL10 immune signaling adaptor

Type

protein-coding

Position

85,265,776–85,276,632 (−)

Aliases

CARMEN, CIPER, CLAP, IMD37, c-E10, mE10

Ensembl

ENSG00000142867

RefSeq RNA

NM_001320715.2, NM_003921.5, XM_011542397.4, XM_011542398.3, XM_011542399.3

RefSeq protein

NP_001307644.1, NP_003912.1, XP_011540699.1, XP_011540700.1, XP_011540701.1

This gene was identified by its translocation in a case of mucosa-associated lymphoid tissue (MALT) lymphoma. The protein encoded by this gene contains a caspase recruitment domain (CARD), and has been shown to induce apoptosis and to activate NF-kappaB. This protein is reported to interact with other CARD domain containing proteins including CARD9, 10, 11 and 14, which are thought to function as upstream regulators in NF-kappaB signaling. This protein is found to form a complex with MALT1, a protein encoded by another gene known to be translocated in MALT lymphoma. MALT1 and this protein are thought to synergize in the activation of NF-kappaB, and the deregulation of either of them may contribute to the same pathogenetic process that leads to the malignancy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016].

via MyGene.info

Gene · Ensembl

BCL10 immune signaling adaptor

Symbol

BCL10

Biotype

Protein coding

Organism

Homo sapiens

Location

1:85,265,776-85,276,640

Strand

Reverse (−)

Assembly

GRCh38

Wikidata facts

via Wikidata · CC0