CARD14

Also known as BIMP2, CARMA2, PRP, PSORS2, PSS1, caspase recruitment domain family member 14

Caspase recruitment domain-containing protein 14, also known as D-containing MAGUK protein 2 (Carma 2), is a protein in the CARD-CC protein family that in humans is encoded by the CARD14 gene.

Gene data

CARD14

Name: caspase recruitment domain family member 14
Type: protein-coding
Position: 80,169,992–80,216,073 (+)
Aliases: BIMP2, CARMA2, PRP, PSORS2, PSS1
Ensembl: ENSG00000141527
RefSeq RNA: NM_001257970.1, NM_001366385.1, NM_024110.4, NM_052819.3, NR_047566.2
RefSeq protein: NP_001244899.1, NP_001353314.1, NP_077015.2, NP_438170.1, XP_011523515.1

This gene encodes a caspase recruitment domain-containing protein that is a member of the membrane-associated guanylate kinase (MAGUK) family of proteins. Members of this protein family are scaffold proteins that are involved in a diverse array of cellular processes including cellular adhesion, signal transduction and cell polarity control. This protein has been shown to specifically interact with BCL10, a protein known to function as a positive regulator of cell apoptosis and NF-kappaB activation. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Apr 2012].

Gene Ontology

Biological process

positive regulation of protein phosphorylation signal transduction activation of NF-kappaB-inducing kinase activity tumor necrosis factor-mediated signaling pathway regulation of apoptotic process negative regulation of apoptotic process regulation of canonical NF-kappaB signal transduction positive regulation of canonical NF-kappaB signal transduction

Molecular function

protein binding signaling adaptor activity CARD domain binding

Cellular component

cytoplasm cytoplasm cytoplasm cytosol plasma membrane CBM complex

Pathways

NF-kappa B signaling pathway - Homo sapiens (human)Apoptosis-related network due to altered Notch3 in ovarian cancer

via MyGene.info

Gene · Ensembl

caspase recruitment domain family member 14

Symbol: CARD14
Biotype: Protein coding
Organism: Homo sapiens
Location: 17:80,169,992-80,216,073
Strand: Forward (+)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of: gene

Show 7 more facts

HomoloGene ID: 11469
found in taxon: Homo sapiens
exact match: identifiers.org/ncbigene/79092
genomic end: 78183130
genomic start: 78143791
chromosome: human chromosome 17
cytogenetic location: 17q25.3

Sources (4)

via Wikidata · CC0

~3 min read

Encyclopedic overview

6 sections

Contents

Structure
Function
Link to psoriasis
References
Further reading
External links

Caspase recruitment domain-containing protein 14, also known as D-containing MAGUK protein 2 (Carma 2), is a protein in the CARD-CC protein family that in humans is encoded by the CARD14 gene.

== Structure ==

Excerpted from Wikipedia’s “CARD14” article, available under the CC BY-SA 4.0 licence.